What does PDRN do for your skin?

The skincare industry is constantly evolving, with innovative treatments emerging to address concerns like skin texture, inflammation, congestion, wrinkles, and overall aging. One of the most groundbreaking anti-aging ingredients making waves in the aesthetic world is PDRN (Polydeoxyribonucleotide), derived from salmon sperm.

PDRN (polydeoxyribonucleotides or polynucleotides) is a popular ingredient in cosmetology. Initially used exclusively in injections, it is now also included in daily skincare products. It helps prevent aging, fights wrinkles, accelerates skin regeneration, and treats issues like alopecia or hard-to-heal wounds. This guide explores what PDRN is, how it works, who it’s suitable for, and how to combine it with other active ingredients.

What is PDRN and how does it work?

PDRN are DNA fragments that repair skin cells damaged by aging or oxidative stress. They work selectively by replacing destroyed nitrogen bases without altering the genetic code or causing allergic reactions.

PDRN is extracted from fish roe—commonly salmon or sturgeon—due to its high similarity to human DNA. It can also be derived from plant-based sources such as ginseng or green tea.

It has several properties :

1. Anti-inflammatory- PDRN helps reduce inflammation by suppressing the expression of proinflammatory cytokines.

2. Tissue regeneration- can help regenerate skin cells and improve skin barrier.

3. Wound healing- can help accelerate the healing process of diabetic wounds.

4. It is now being widely used as fillers.

When fragmented to a size below 500 daltons, PDRN can easily penetrate the skin barrier and reach deeper layers.

 

How Does Pdrn Affect The Skin?

1. DNA repair: PDRN identifies and repairs damaged DNA in aged skin cells, restoring firmness and elasticity, reducing wrinkle depth, and combating sagging.

2. Stimulates collagen and elastin production: Polynucleotides boost the production of these essential proteins, strengthening the skin’s structure.

3. Deep hydration: Thanks to their moisturizing properties, the skin becomes softer, smoother, and well-nourished.

4. Antioxidant protection: PDRN neutralizes free radicals, slowing down the aging process.

5. Reduces pigmentation: By inhibiting tyrosinase and melanin production, it helps fade dark spots and even out skin tone.

6. Anti-inflammatory and regenerative effect: It accelerates tissue healing and reduces inflammation, making it ideal after aggressive cosmetic procedures.

 

Polydeoxyribonucleotide Skin Benefits

1. Skin Texture & Wrinkles: How PDRN Improves Collagen & Elasticity

As we age, our skin loses collagen and elastin, leading to fine lines, wrinkles, and loss of firmness. PDRN stimulates fibroblast activity, encouraging the production of new collagen and strengthening the skin’s structure.

With repeated treatments, you’ll notice:

• Smoother skin texture
• Reduction in fine lines and crepey skin
• Enhanced elasticity and bounce

At Clemens Face + Body, we recommend a series of microneedling sessions with PDRN to restore youthful skin while maintaining a natural, refreshed look.

2. Inflammation & Redness: PDRN’s Healing Properties

Inflammation is at the root of many skin concerns, including rosacea, sensitivity, and redness. PDRN has powerful anti-inflammatory and wound-healing properties, making it an ideal treatment for:

• Post-inflammatory redness from acne
• Rosacea and sensitive skin conditions
• Damaged, compromised skin barriers

Unlike traditional treatments that simply mask symptoms, PDRN heals the skin from within, promoting long-term resilience and balance.

3. Skin Congestion & Clogged Pores: How PDRN Clears & Detoxifies

Congested skin, clogged pores, and bumpiness are often caused by poor cellular turnover and inflammation. By accelerating skin renewal, PDRN gently resurfaces the skin, improving:

• Breakout-prone, congested skin
• Rough, bumpy skin texture
• Post-acne scarring and hyperpigmentation

Paired with microneedling, this treatment allows deeper product absorption, ensuring that PDRN reaches the skin layers where true transformation happens.

4. Overall Anti-Aging: Why PDRN is the Ultimate Skin Rejuvenator

If you’re looking for a comprehensive anti-aging solution, PDRN offers:

• Deep hydration and plumping effects
• A natural glow and improved skin radiance
• Long-term cellular repair and age prevention

Unlike fillers or Botox, which primarily address volume loss and wrinkles, PDRN enhances overall skin quality, working from the inside out to restore youthful vitality.

 

 

Who is PDRN suitable for?

1. People focused on preventing aging: If you’re over 25–30 and want to delay wrinkles or maintain skin elasticity, PDRN is a great choice.

2. Those with mature skin: For visible wrinkles, loss of firmness or sagging, PDRN revitalizes and regenerates the skin.

3. Sensitive or damaged skin: Due to its soothing and healing properties, it works well for irritated or inflamed skin and minor wounds.

4. After cosmetic procedures: Perfect for recovery after chemical peels, microdermabrasion, injections, or aesthetic surgery.

5. Specific skin concerns: Useful for post-inflammatory pigmentation, acne scars, or alopecia.

Note: If you have highly reactive skin or serious skin conditions (eczema, psoriasis), consult a dermatologist before use.

 

How to use PDRN?

PDRN is available in creams, serums, and masks. On the ingredient list, look for Sodium DNA, DNA-Na, or Hydrolyzed DNA. The usual concentration ranges between 0.1% and 3%, which is sufficient for visible results.

 

What pairs well with PDRN?

Exfoliating acids (AHA/BHA): Glycolic or salicylic acid removes dead skin cells, while PDRN supports regeneration.
➤ Apply the acid, wait 15–20 minutes, then apply PDRN.

Retinoids: Retinol stimulates collagen, and PDRN calms and repairs the skin.
➤ Apply retinol at night, wait 10–15 minutes, then follow with PDRN.

Spicules: Micro-injuries from spicules heal faster when followed by PDRN application.
➤ Ideal for boosting recovery and reducing inflammation.

Peptides: Together with PDRN, they enhance skin firmness and elasticity.

Hyaluronic acid: Deep hydration combined with PDRN gives plump, smooth skin.

Niacinamide: Works alongside PDRN to even out skin tone and reduce sensitivity.

 

What not to combine with PDRN?

Vitamin C in acidic forms: Pure ascorbic acid can destabilize PDRN.
➤ Apply separately — Vitamin C in the morning, PDRN in the evening.

Tips for combining PDRN with active ingredients:

PDRN + Spicules:
▸ Evening: apply spicules in a serum (step 1), then follow with a PDRN cream (step 2).
▸ Tip: 1–2 times/week + hydrating cream (step 3).

PDRN + Retinol:
▸ Evening: apply retinol serum after cleansing (step 1), wait 10–15 min, then apply PDRN cream (step 2).
▸ Tip: start with 0.2–0.5% retinol, every other night if skin is sensitive.

PDRN + Acids (AHA/BHA):
▸ Evening: apply acids in a serum (step 1), wait 15–20 min, then PDRN cream (step 2).
▸ Tip: acids 1–2 times/week, PDRN more frequently, don’t mix directly.

PDRN + Peptides:
▸ Morning: peptides in serum (step 1), evening: PDRN serum or cream (step 1), or combined in one serum.
▸ Tip: great for daily use, especially for mature skin.

PDRN + Hyaluronic acid:
▸ Evening: PDRN in serum (step 1), then hyaluronic acid in cream (step 2), or combined in one product.
▸ Tip: daily use, especially for dry skin.

PDRN + Niacinamide:
▸ Morning: niacinamide serum (step 1), evening: PDRN cream (step 1) or both together in a serum.
▸ Tip: daily use, excellent for sensitive skin.

PDRN + Gentle antioxidants:
▸ Morning: antioxidant serum (step 1), evening: PDRN cream (step 1), or use both together in the morning.
▸ Tip: daily use to prevent aging.

PDRN also works perfectly on its own, without needing to be combined with other actives.
— In serums, it’s great in the morning as a regenerative and antioxidant base under SPF.
— In creams, it’s ideal for nighttime use to hydrate and repair the skin while you sleep.

Conclusion

In conclusion, PDRN offers a wide range of benefits for the skin. From enhancing hydration and reducing inflammation to promoting skin regeneration and protecting against environmental damage, it is a versatile compound that can address multiple skin concerns. Whether you are looking to improve the appearance of fine lines and wrinkles, soothe irritated skin, or achieve a more radiant complexion, PDRN may be a valuable addition to your skincare routine. However, as with any skincare ingredient, it is important to consult with a qualified professional before incorporating PDRN into your regimen, especially if you have any underlying skin conditions or concerns. Yangge Biotech manufactured polydeoxyribonucleotide powder with the highest quality contact us today to add this ingredient to your skincare products! Email: info@yanggebiotech.com