Yangge Biotech's Spermidine 98% is a premium-quality, high-purity nutraceutical ingredient manufactured under strict quality management systems to ensure exceptional purity, stability, and batch-to-batch consistency. Standardized to 98% spermidine, this advanced ingredient is widely used in dietary supplements, healthy aging formulations, cellular wellness products, longevity-focused nutraceuticals, and functional food applications. It is an ideal ingredient for manufacturers seeking a highly concentrated spermidine solution for premium health and wellness product development.

Looking for a reliable Spermidine 98% supplier? Contact Yangge Biotech today to request product specifications, COA, samples, pricing, or OEM/ODM manufacturing solutions.

Email: info@yanggebiotech.com

What Is Spermidine 98%?

Spermidine 98% has the chemical structure formula C7H19N3. It comprises one amine group (NH) and two amino groups (NH2). Its molecular formula is shown below. It belongs to a colorless transparent crystal. Spermidine contains three nitrogen atoms in its chemical structure. Bulk spermidine powder has certain chemical and biological activities.

Spermidine 98% supplier Yangge Biotech

COA:

Test Items	Specification	Result	MOA
Appearance	White to off-white powder	Off-White Powder	Visual
Purity	≥98%	99.0%	GC
Solubility	Soluble in water	Conform	CP2020
Loss on drying	≤1.0%	0.28%	CP2020
Residue on ignition	0.2%	0.02%	CP2020
Ethanol(GC)	5000ppm	600ppm	GC
Heavy Metal Content
Pb	≤0.1 ppm	Conform	GB5009
Hg	≤0.1ppm	Conform	GB5009
Cd	≤0.2 ppm	Conform	GB5009
As	≤0.1ppm	Conform	GB5009
Total microbial count	≤500CFU/g	<10	GB4789
Coliform	≤0.92MPN/g	Conform	GB4789
Mold and yeast	≤50CFU/g	Conform	GB4789
Staphylococcus aureus	0/25g	Conform	GB4789
Salmonella	0/25g	Conform	GB4789
Conclusion	All inspection items are in conformity with the specifications.
Storage Condition	Sealed packaging, stored at cool, dry, and away from light.

Spermidine 98% Source

spermidine 98% powder is found in many foods. It is especially high in legumes, whole grains, fermented foods, mushrooms, and some fruits. The body can synthesize spermidine itself. This takes place mainly in the liver, kidneys, and small intestine. However, the amount of spermidine produced by the body itself is affected by age, diet, gut microbiota genetic factors, etc. The amount of spermidine synthesized by the body itself begins to decline after the age of 30, and the decline becomes more pronounced after the age of 40.

Extraction Methods:

Yangge Biotech uses two methods to extract spermidine powder has two processes: plant extraction and bio-fermentation. Nowadays, the spermidine products on the market are mainly extracted from rice or wheat germ as raw material.

1. Plant-extracted spermidine

Plant-derived spermidine (Spermidine) production method is a method of extracting spermidine by physical and chemical means using natural plants as raw materials.

•Raw material selection and pretreatment:

The first step of plant-derived spermidine is to select the appropriate plant raw material. We use wheat germ, which is rich in spermidine. The quality of the raw material directly affects the purity and yield of the final extract, so it needs to be strictly screened and tested. After selecting the raw material, it must be pre-treated by washing, drying, and crushing.

•Solvent extraction:

The pre-treated plant powder needs to be extracted using a suitable solvent. The purpose of this step is to dissolve bulk spermidine powder from the plant matrix. During the extraction process, temperature, pH, and time need to be controlled.

•Purification and concentration:

The extracted solution contains a variety of plant compounds. This requires a multi-step purification process to isolate and concentrate spermidine. Commonly used purification methods include membrane filtration, ion exchange chromatography, and liquid-liquid extraction. These methods can effectively remove impurities and improve the purity of bulk spermidine powder. Subsequently, the extract must be concentrated by evaporation, lyophilization, etc.

•Detection and quality control:

The extracted and purified bulk spermidine powder needs to undergo rigorous quality testing. Commonly used detection methods include high-performance liquid chromatography (HPLC) and mass spectrometry. These detection techniques can accurately determine the content of spermidine and detect the level of impurities in it.

•Packaging:

The packaging process requires strict control of environmental conditions to prevent degradation and contamination of spermidine. After packaging, the product undergoes a final quality inspection.

Spermidine 98% supplier Yangge Biotech

Advantages of Yangge spermidine powder

•naturalness:

Plant-extracted spermidine is derived from natural plants and has high safety and biocompatibility. Compared with chemically synthesized spermidine, plant-extracted products are more in line with modern consumers' pursuit of natural and healthy products.

•Diversity:

Plants are rich in a variety of beneficial bioactive substances. In addition to bulk spermidine powder, it may also contain other ingredients that are beneficial to health. Such as antioxidants, vitamins, etc. Therefore, plant-derived spermidine products may have a wider range of health effects.

•Environmental friendliness:

The plant extraction process usually uses milder solvents and techniques. This reduces environmental pollution. The plant extraction process is more environmentally friendly than the chemical synthesis method.

2. Biological Fermentation of Spermidine

Biofermented bulk spermidine powder involves the cultivation of microorganisms, fermentation, and extraction.

(1)Production Process

•Strain Selection:

The production of fermented spermidine first requires the selection of a suitable microbial strain. Microorganisms that are capable of synthesizing spermidine in large quantities are usually selected. These strains are genetically modified or naturally selected to produce spermidine efficiently.

•Fermentation culture:

After selecting a suitable strain, it is placed in a fermenter for cultivation. During fermentation, the microorganisms convert nutrients in the medium into spermidine by metabolic action. Fermentation conditions such as temperature, pH, oxygen supply, and medium composition have a direct effect on the yield of spermidine, so precise control is required.

•Extraction and purification:

After fermentation is completed, bulk spermidine powder needs to be extracted from the fermentation broth. We usually use centrifugation to remove the bacteria and impurities. Then, further purification through liquid chromatography and other techniques, and finally high purity spermidine.

•Concentration and drying:

The purified spermidine solution usually needs to be concentrated and then converted into a powdered product by techniques such as spray drying or freeze drying, so that it can be easily preserved and transported.

(2)Advantages

•Natural source:

Biofermented spermidine is produced through the natural metabolism of microorganisms. It is closer to a natural source than chemically synthesized methods, reducing the risk of chemical contamination and residues.

•Efficient Production:

Advances in modern biotechnology allow the fermentation process to produce high concentrations of bulk spermidine powder in a relatively short period. By optimizing the strain and fermentation conditions, the production efficiency is greatly improved.

•High purity:

Through a rigorous purification process, the purity of bio-fermented spermidine is usually high. This can meet the requirements of food supplements and pharmaceutical applications.

•Environmentally friendly:

The fermentation process generally does not require the use of harmful chemicals. The production process produces less waste and it has less impact on the environment.

•High safety:

Due to the strict control of the bulk spermidine powder production process, bio-fermented spermidine is usually highly safe and suitable for long-term consumption.

Benefits of Kale Extract Powder

Kale Extract Powder offers a wide range of health benefits due to its concentrated levels of essential nutrients and bioactive compounds. It is rich in vitamins A, C, and K, which support immune function, skin health, and proper blood clotting. The presence of antioxidants such as flavonoids and carotenoids helps combat oxidative stress, reducing cellular damage and inflammation.

One of its key benefits is promoting heart health. Kale extract contains potassium and plant compounds that may help regulate blood pressure and support healthy cholesterol levels. Its fiber content also contributes to improved cardiovascular function.

Kale extract powder supports bone health through its high vitamin K and calcium content, which are essential for maintaining strong bones and reducing the risk of bone-related conditions. Additionally, it aids in digestive health by supporting gut function and promoting regularity.

The chlorophyll and phytonutrients found in kale extract may also assist in detoxification, helping the body eliminate toxins naturally. Furthermore, its antioxidant properties contribute to skin health, supporting a clearer, more youthful appearance.

Spermidine 98% supplier Yangge Biotech

Spermidine 98% Functions

1. Inhibition of Neuronal NOS: It can inhibit neuronal nitric oxide synthase (nNOS), an enzyme responsible for the production of nitric oxide in neurons. This helps regulate nitric oxide levels in the brain, which are crucial for neuronal signaling and function.

2. DNA Binding and Stabilization: Has the ability to bind and stabilize DNA molecules. It can interact with the negatively charged phosphate groups of DNA, neutralizing their charge and promoting DNA condensation and stability.

3. Stimulation of Enzymatic Activity: Stimulating the activity of enzymes like T4 polynucleotide kinase, which is involved in DNA repair and replication.

4. Anti-Aging Effects: Recent studies have suggested that it may have anti-aging effects. It can induce autophagy, a cellular process that helps remove damaged or dysfunctional proteins and organelles, promoting cellular rejuvenation.

5. Cancer Prevention: It has been shown to reduce the risk of cancer development. It can suppress tumor growth and enhance antitumor immune responses.

Spermidine 98% supplier Yangge Biotech

What Is Spermidine 98% Used For?

Spermidine 98% powder has gained attention for its potential health benefits and has been used in dietary supplements, cosmetics, and pharmaceuticals.

● In dietary supplements
Spermidine 98% powder is marketed as an anti-aging product. It is claimed to stimulate autophagy, a cellular process that removes damaged or unnecessary components, which is believed to promote longevity and prevent age-related diseases. Spermidine supplements are also marketed to support cardiovascular health, brain function, and hair growth.

● In cosmetics
It has been incorporated into skincare products for its potential anti-aging properties. It is claimed to rejuvenate the skin by enhancing cell renewal and promoting collagen production.

● In pharmaceuticals
It has shown promise in various studies for its potential to treat or prevent neurodegenerative diseases, and age-related disorders. It has demonstrated anti-inflammatory and antioxidant properties, which may help to protect against oxidative stress and cellular damage.

Tips On Improving Spermidine Levels

1. Dietary Intake of Spermidine-Rich Foods

Incorporate foods high in spermidine into your diet, such as aged cheese, soybeans, peanuts, wheat germ, and whole grains. These foods naturally contain it and can help increase its levels in the body.

Consume fermented foods like kimchi, sauerkraut, and yogurt, as the fermentation process often results in increased content.

Incorporate a variety of fruits and vegetables into your diet, as some contain spermidine precursors that can be converted by the body.

2. Lifestyle Modifications

Exercise regularly. Moderate to high-intensity exercise has been linked to increased levels. Cardiovascular exercises like running, swimming, and cycling are good choices.

Reduce stress levels. Chronic stress can negatively impact levels. Incorporate stress-reduction techniques like meditation, yoga, and deep breathing exercises into your daily routine.

Maintain a healthy weight. Obesity has been associated with lower levels. Adopt a balanced diet and regular exercise to maintain a healthy weight.

Quit smoking and limit alcohol consumption. These habits can negatively impact levels and overall health.

3. Supplementation

Consider taking spermidine supplements. While dietary sources are preferred, supplements can be a viable option for individuals who have difficulty incorporating spermidine-rich foods into their diet.

When choosing a supplement, ensure it comes from a reputable source and is certified for quality and purity.

Follow the recommended dosage instructions on the supplement label and consult a healthcare professional if you have any questions or concerns.

4. Other Considerations

Increase your intake of antioxidants. Antioxidants can help protect spermidine from oxidative damage, maintaining its stability and bioavailability. Foods rich in antioxidants include berries, nuts, and dark chocolate.

Drink plenty of water. Staying hydrated is essential for maintaining optimal levels and overall health.

Consider taking a probiotic supplement. Probiotics can help support a healthy gut microbiota, which may contribute to increased production.

Remember, improving spermidine levels is a gradual process that requires consistency and patience. Adopting a healthy diet, lifestyle, and supplementation plan can help you achieve your goals and maintain optimal levels for overall health and well-being.

Applications of Kale Extract Powder

Kale Extract Powder is widely utilized across the nutraceutical, food, and cosmetic industries due to its concentrated nutrient profile and high antioxidant content. In the dietary supplement industry, it is commonly formulated into capsules, tablets, and powdered drink mixes designed to support daily nutrition, detoxification, and overall wellness. Its richness in vitamins, minerals, and phytonutrients makes it a key ingredient in green superfood blends.

In the food and beverage sector, kale extract powder is incorporated into smoothies, juices, protein shakes, and functional beverages to enhance nutritional value. It is also used in bakery products, nutrition bars, soups, and sauces, providing a natural source of plant-based nutrients without significantly affecting flavor when properly formulated.

Within the cosmetics and personal care industry, kale extract is valued for its antioxidant properties and is used in skincare formulations such as creams, serums, and face masks. It helps protect the skin from environmental stressors and supports a healthy, radiant appearance.

Additionally, kale extract powder is applied in animal nutrition to improve the nutrient content of feed. Its clean-label, plant-based nature makes it ideal for organic, vegan, and health-focused product development across global markets.

Spermidine 98% supplier Yangge Biotech

Your Trusted Spermidine 98% Manufacturing Partner

If you are looking for a reliable Spermidine 98% supplier for your next product, Yangge Biotech is your trusted manufacturing partner. We provide premium-quality Spermidine 98% Powder for nutraceutical, pharmaceutical, food, beverage, and dietary supplement manufacturers worldwide.

Our advanced production facility manufactures high-purity Spermidine 98% Powder using advanced production technology and strict quality control systems. Every batch undergoes comprehensive testing to ensure consistent purity, potency, stability, and batch-to-batch performance, meeting the quality standards required by international manufacturers and brand owners.

As one of the experienced Spermidine Powder Manufacturers and a professional Spermidine Powder Factory, Yangge Biotech offers flexible bulk packaging, OEM/ODM manufacturing, private labeling, customized specifications, and reliable global logistics. Whether you require standard Spermidine 98% Powder or customized longevity and healthy aging formulations, our experienced technical team can provide tailored support for your product development and manufacturing requirements.

Our premium Spermidine 98% Powder is widely used in healthy aging supplements, cellular wellness products, cognitive health formulations, functional foods, beverages, capsules, tablets, gummies, and advanced nutritional products. With stable production capacity, competitive factory pricing, and dependable worldwide delivery, we help global brands develop innovative wellness products.

As a trusted Spermidine Powder Manufacturer, Yangge Biotech provides dependable bulk supply, comprehensive technical documentation including COA, MSDS, and specification sheets, and customized ingredient solutions to support international product development and regulatory compliance. For customers searching for Spermidine in Chinese, the ingredient is commonly referred to as 亚精胺 (Yàjīng'àn) in the Chinese market.

Whether you are sourcing Spermidine 98% Powder, searching for experienced Spermidine Powder Manufacturers, looking for a dependable Spermidine Powder Factory, or seeking a reliable long-term manufacturing partner, Yangge Biotech is committed to delivering premium-quality ingredients, responsive customer service, competitive pricing, and a reliable global supply chain.

Company Introduction And Certificates Obtained

Third Part Test Result

We have established partnerships with prestigious third-party laboratories, including Eurofins and SGS. Upon customer request, we are capable of arranging reinspection of Spermidine 98% Manufacturer samples prior to shipment. Furthermore, we are fully equipped to coordinate testing with any laboratory designated by the customer to ensure their specific requirements are met.

Spermidine 98% supplier Yangge Biotech

OEM Packaging Available

Yangge Biotech offers OEM packing services, private label manufacturing, and custom packaging solutions for businesses worldwide. We accept customer designs, custom logo printing, private label, white label, and OEM packaging tailored to your brand. Whether you need stand-up pouches, bottles, jars, sachets, or bulk packaging, we deliver high-quality, market-ready products with flexible MOQ and professional production standards.

Launch your brand with our one-stop OEM, private label, and custom packaging services. Contact us today for a customized solution. Email:info@yanggebiotech.com

OEM services by yanggebiotech

Yangge Biotech Certificates

At Yangge Biotech, quality is at the core of everything we do. We are committed to continuous manufacturing improvement and strict quality management. Our Spermidine 98% and manufactured ingredients are backed by internationally recognized certifications, including ISO, HACCP, GMP, Kosher, and other relevant industry certifications, demonstrating our commitment to quality, safety, and global compliance.

yangge biotech certificate

FAQ

※ Do you have factory?

Yes, we have a 1500m2 factory with modern equipment, welcome to visit our factory. When you have the details schedule, please kindly let me know in advance.

※ Do you have GMP?

All of our products are produced according to GMP standard, meanwhile, we have obtained ISO22000, Certificate and so on.

※ What is your delivery time?

As usual, our delivery time is about 1~3 days after receipt of payments, however, for some special products, please kindly confirm with your sales manager in advance.

※ How can you confirm your quality?

Each batch of the goods can be shipped to you after strict inspection, if you still doubt, we can arrange the Pre-shipment Samples to your testing or to your pointed third party for retesting in advance, successfully, then we will arrange the bulk goods to you immediately.

R&D Technological Process

Yangge Biotech's experienced R&D team continuously develops and optimizes production technologies to improve product quality, stability, and performance. Through advanced research, process optimization, rigorous testing, and strict quality control, Yangge Biotech ensures innovative, reliable, and high-quality ingredients that meet the evolving needs of the global food, beverage, nutraceutical, and cosmetic industries.

yangge biotech Technological Process

Exhibitions

Yangge Biotech actively participates in leading international trade exhibitions, including CPhI, FIC, API China, Vitafoods, and SupplySide West, connecting with global partners, showcasing our latest products, and staying at the forefront of industry innovation.

yangge Biotech Exhibitions

Yangge Biotech Factory

Yangge Biotech operates a modern manufacturing facility equipped with advanced production equipment and strict quality control systems. From raw material sourcing to production, testing, and packaging, every stage is carefully managed to ensure consistent quality, product safety, and compliance with international manufacturing standards.

- All goods are manufactured in GMP standard facilities.

- All goods are released after inspection by our independent laboratory or third party.

- All goods are transported by professional freight companies.

Yangge Biotech Factory

Contact Yangge Biotech for Spermidine 98%

Looking for a reliable Spermidine 98% manufacturer, supplier, or OEM private label partner? Yangge Biotech offers multiple specifications to meet your product development needs. We provide 10–30 g free samples, competitive bulk pricing, and maintain 500 kg monthly stock in our U.S. warehouse for fast and efficient delivery.

We can also provide all essential technical documents, including the Certificate of Analysis (COA), MSDS, Specification Sheet, Test Reports, and a customized quotation upon request.

Contact us today to request free samples, pricing, OEM/private label services, or product documentation.

Email: info@yanggebiotech.com