Natural Spermidine (C14)

Yangge Biotech's supplies Natural Spermidine, a plant-derived polyamine ingredient extracted from the germ of Triticum aestivum (wheat). As a naturally occurring compound associated with cellular autophagy and renewal, spermidine is increasingly used in advanced nutraceutical, healthy-aging, longevity, and functional food formulations.

Looking for a reliable Polydeoxyribonucleotide (PDRN) supplier? Contact Yangge Biotech today to request product specifications, COA, samples, pricing, or OEM/ODM manufacturing solutions.

Email: info@yanggebiotech.com

What is Natural Spermidine Powder?

Natural Spermidine is a naturally occurring polyamine compound extracted from the germ of Triticum aestivum (wheat). Spermidine plays an important role in cellular maintenance and is widely studied for its role in supporting autophagy, the body’s natural process of removing damaged cellular components and recycling them for renewal.

Unlike synthetic or isolated spermidine, Yangge Biotech Natural Spermidine is derived from a natural botanical source and retains a broader polyamine profile, including spermidine, spermine, and putrescine. This naturally occurring combination more closely reflects the polyamine environment found in biological systems, supporting a biomimetic approach to cellular maintenance and renewal.

Product Specifications

COA

Source & Botanical Origin

Yangge Biotech Natural Spermidine is derived from carefully selected Non-GMO wheat germ (Triticum aestivum), providing a natural source of spermidine and supporting polyamines. Raw material authenticity is verified through DNA barcoding, helping confirm the botanical identity and consistency of the wheat germ used in production.

Through controlled sourcing and processing, Yangge Biotech selects wheat germ with a naturally rich polyamine profile and processes it under controlled conditions to help preserve its naturally occurring spermidine content. This approach supports consistent quality, reliable specifications, and a natural ingredient profile suitable for nutraceutical, healthy-aging, longevity, and functional food applications.

Mechanism of Action (Mitophagy Activation)

Spermidine functions by inhibiting the acetyltransferase EP300, which induces systemic autophagy. At a molecular level, it activates the PINK1/Parkin-mediated pathway, which identifies and clears dysfunctional mitochondria. This mechanism may support mitochondrial fitness and proteostasis, supporting functional defense against cellular senescence signaling.

Spermidine Powder Benefits

Longevity Active: Functional property for systemic cellular detoxification via autophagy.

Dermal Integrity: May support the functional property of hair follicle stimulation and epidermal thickness.

Cognitive Support: Functional active in supporting neuro-synaptic integrity.

Bio-Compatible: 100% plant-derived matrix ensures high metabolic affinity.

Applications

1. Dietary Supplements
Capsules, tablets, and softgels targeting cellular health, autophagy support, and metabolic balance.

2. Functional Beverages & Powders
Incorporated into protein shakes, energy blends, or plant-based drink formulations; often combined with polyamines, vitamins, or antioxidants for synergistic effects.

3. Research & Clinical Studies
Used in autophagy research, age-related metabolic studies, and formulation testing for stability and bioavailability.

4. Complex Formulations
Can be integrated with other anti-aging or cellular wellness actives, e.g., resveratrol, spermidine precursors, or micronutrients, with attention to pH and stability compatibility.

Usage & Formulation Guide

Dissolution: Yangge biotech's Spermidine is Cold Water Dispersible (CWD). It achieves instant aqueous clarity in room-temperature formulations.

pH Stability: Maintains molecular integrity between pH 3.0 and 6.5. In alkaline environments (pH > 7.5), polyamines are prone to auto-oxidation.

Temperature Control: Thermolabile. Do not exceed 50°C during industrial mixing to prevent polyamine degradation. Add to the final stage of formulation.

Why Choose Yangge Biotech's Spermidine Powder?

1. China Factory Supply & Stable Production
Yangge biotech manufactures spermidine hydrochloride powder with stable production capacity and bulk supply capability for global supplement brands.

2. Ultra-High Purity & Quality Verification
≥98% HPLC-verified spermidine content ensures accurate formulation performance.Each batch is tested with analytical data including spermidine assay, heavy metals and microbial limits, with batch-specific CoA available.

3. Controlled Processing & Stable Packaging
Controlled particle size, moisture level and nitrogen-flushed packaging help maintain product stability during storage and transportation.

4. Flexible OEM & Formulation Support
We support customized packaging, private label projects and formulation guidance based on different dosage forms including capsules, tablets and powder blends.

Third Part Test Result

We have established partnerships with prestigious third-party laboratories, including Eurofins and SGS. Upon customer request, we are capable of arranging reinspection of Natural Spermidine (C14) samples prior to shipment. Furthermore, we are fully equipped to coordinate testing with any laboratory designated by the customer to ensure their specific requirements are met.

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OEM Packaging Available

Yangge Biotech offers OEM packing services, private label manufacturing, and custom packaging solutions for businesses worldwide. We accept customer designs, custom logo printing, private label, white label, and OEM packaging tailored to your brand. Whether you need stand-up pouches, bottles, jars, sachets, or bulk packaging, we deliver high-quality, market-ready products with flexible MOQ and professional production standards.

Launch your brand with our one-stop OEM, private label, and custom packaging services. Contact us today for a customized solution. Email:info@yanggebiotech.com

Yangge Biotech certificates

Over the years, we have been committed to the product manufacture optimization and quality system establishment. And we have obtained the Certificate for Natural Spermidine (C14) and all our manufactured products.

FAQ

※ Do you have factory?

Yes, we have a 1500m2 factory with modern equipment, welcome to visit our factory. When you have the details schedule, please kindly let me know in advance.

※ Do you have GMP?

All of our products are produced according to GMP standard, meanwhile, we have obtained ISO22000, Certificate and so on.

※ What is your delivery time?

As usual, our delivery time is about 1~3 days after receipt of payments, however, for some special products, please kindly confirm with your sales manager in advance.

※ How can you confirm your quality?

Each batch of the goods can be shipped to you after strict inspection, if you still doubt, we can arrange the Pre-shipment Samples to your testing or to your pointed third party for retesting in advance, successfully, then we will arrange the bulk goods to you immediately.

Technological Process

Yangge Biotech's experienced R&D team continuously develops and optimizes production technologies to improve product quality, stability, and performance. Through advanced research, process optimization, rigorous testing, and strict quality control, Yangge Biotech ensures innovative, reliable, and high-quality ingredients that meet the evolving needs of the global food, beverage, nutraceutical, and cosmetic industries.

Exhibitions

We often attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.

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Yangge Biotech Factory

- All goods are manufactured in GMP standard facilities.

- All goods are released after inspection by our independent laboratory or third party.

- All goods are transported by professional freight companies.

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Partner With Yangge Biotech For High Quality Natural Spermidine (C14)

For Natural Spermidine (C14) there are different specification for your choice, we can provide 10-30g of free samples, US warehouse in stock of 500kg of each month for the market of the global. certificate of analysis (COA), MSDS, specification sheet, pricing quotation is obtainable upon your request.

If you have any question or need any documents, welcome to contact us by e-mail: info@yanggebiotech.com