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L-Ergothioneine (99.99%)
Product Name: Ergothioneine | Industrial Bulk Supply
Assay (HPLC): ≥99.0% (Certified Enantiomerically Pure L-Isolate)
Appearance: White Crystalline Powder (Uniform 80 Mesh)
Solubility: Highly Water-Soluble (Instant Aqueous Clarity)
Stability: Thermostable to 80°C | Optimal between pH 3.0 – 9.0
Packaging: 25kg Standard Fiber Drum / 1kg Sample Available
Compliance: GMP Certified / Full Batch COA & Technical Dossier
Application: Mitochondrial Longevity Supplements / Dermaceuticals
OEM & ODM Services
- Fast Delievery
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Yangge Biotech's Ergothioneine Manufacturer: 99% Pure Bio-fermented Isolate For Healthy Aging, Dietary Supplements
Yangge Biotech supplies high-purity L-Ergothioneine (99.99%), a rare, naturally occurring sulfur-containing amino acid betaine known for its antioxidant properties. Produced through advanced bio-fermentation, our L-Ergothioneine offers excellent purity and consistency for use in nutraceutical, longevity, functional food, and skincare formulations.
Looking for a reliable L-Ergothioneine Powder manufacturer or bulk supplier? Contact our team today to request pricing, free samples, COA, third-party test reports, or customized OEM/ODM manufacturing solutions.
Email: info@yanggebiotech.com
What Is L-Ergothioneine (99.99%)?
L-Ergothioneine (99.99%) is a rare, naturally occurring sulfur-containing amino acid betaine known for its powerful antioxidant properties. Unlike ordinary antioxidants, it is actively transported into cells through the OCTN1 transporter, helping support protection against oxidative stress. Produced through advanced bio-fermentation, our ultra-pure L-Ergothioneine offers excellent purity, stability, and consistency for longevity, nutraceutical, and advanced skincare formulations.
Technical Specifications Table
| Parameter | Industrial Specification |
|---|---|
| Isomer Verification | 100% L-isomer (D-isomer < 0.1%) |
| Identification (FTIR) | Conforms to Reference Standard |
| Moisture (LOD) | ≤ 1.0% |
Source & Origin
Yangge Biotech L-Ergothioneine is produced through advanced bio-fermentation using non-GMO Saccharomyces cerevisiae strains. This process follows the natural biosynthesis pathway found in mushrooms while delivering high purity and consistent quality at commercial scale. The fermentation-based process provides a clean-label ingredient without relying on heavy-metal catalysts used in some chemical synthesis methods.
Mechanism of Action
L-Ergothioneine works by being actively transported into cells through the OCTN1 transporter. It can then accumulate in important parts of the cell, including the mitochondria and nucleus, where it helps neutralize harmful free radicals and protect cells from oxidative stress. Its stable structure also helps maintain its antioxidant activity without readily becoming a pro-oxidant.
L-Ergothioneine Benefits
L-Ergothioneine Powder is a versatile ingredient used in nutraceuticals, functional foods, cosmetics, and advanced skincare.
*Powerful Antioxidant – Helps neutralize free radicals and protect cells from oxidative stress.
*Cell Protection – Helps protect cells from environmental and UV-related oxidative damage.
*Skin Support – Supports skin protection and may help reduce signs of photoaging.
*Anti-Inflammatory Support – Helps support the body’s natural response to oxidative and inflammatory stress.
*Eye Health – Supports antioxidant protection for the eyes and is being explored for ophthalmic applications.
*Organ Protection – Its stability and antioxidant activity make it a potential ingredient for organ preservation and transplantation research.
Applications of L-Ergothioneine Powder
Ergothioneine Powder is a naturally occurring amino acid antioxidant commonly derived from mushrooms and certain microorganisms. It is widely used in the nutraceutical, cosmetic, pharmaceutical, and functional food industries due to its strong antioxidant and cell-protective properties. In the dietary supplement industry, ergothioneine powder is formulated into capsules, tablets, and powdered blends designed to support healthy aging, cognitive wellness, and immune function. It is often included in premium antioxidant and longevity-focused formulations.
In the functional food and beverage sector, ergothioneine is incorporated into wellness drinks, nutrition bars, and fortified foods aimed at enhancing antioxidant intake and supporting cellular health. Its stability and compatibility with various formulations make it suitable for advanced health products.
Within the cosmetics and skincare industry, ergothioneine powder is widely used in anti-aging creams, serums, masks, and lotions. Its antioxidant properties help protect skin cells from environmental stressors such as pollution and UV exposure, supporting healthier and more youthful-looking skin.
Additionally, in the pharmaceutical and clinical nutrition fields, ergothioneine is being researched for its potential role in neuroprotection, mitochondrial health, and inflammation management. Its multifunctional benefits make it a highly valuable ingredient in modern wellness and beauty applications.
Usage & Formulation Guide
High L-Isomer Purity
Our L-Ergothioneine is tested for high L-isomer purity to help ensure consistent performance and reliable activity in your formulations.
Good Heat Stability
L-Ergothioneine has good thermal stability and can be added during certain heating steps, making it suitable for a variety of industrial formulation processes.
Industrial Evolution
L-Ergothioneine production has evolved from mushroom extraction and chemical synthesis to advanced fermentation. Our fermentation-based process provides a high-purity, non-GMO, and solvent-free ingredient suitable for clean-label, nutraceutical, and pharmaceutical applications.
COA
|
Items |
Specifications |
Test Results |
Methods |
|
Purity |
≥99.9% |
99.92% |
HPLC(Internal Standard Method) |
Physical & Chemical Control |
|||
|
Appearance |
White crystal |
Conform |
Visual observation |
|
Smell |
Characteristic odor |
Conform |
Nose smells |
|
pH(50mg/mL,20℃) |
6.0-7.5 |
6.38 |
pH meter |
|
Melting Point (Decompose) |
270-271℃ |
270.4℃ |
Melting point detector |
|
Optical Rotation |
[a]D≥(+)122°(c= 1,H₂O) |
+124.9° |
Polarimeter (c= 1,H₂O) |
|
Crystallite size |
100% pass rate for 50 mesh |
Conform |
Sieve |
|
Density |
0.55-0.75g/mL |
0.66 |
Bulk density meter |
|
Loss on Drying |
<0.5% |
0.07% |
TGA |
|
Total Residual Solvents |
≤200 ppm |
50.06 ppm |
GC |
Heavy Metals Control: |
|||
|
Arsenic |
≤1 ppm |
Conform |
ICP |
|
Lead |
≤1 ppm |
Conform |
ICP |
|
Mercury |
≤0.2 ppm |
Conform |
ICP |
|
Cadmium |
≤0.3 ppm |
Conform |
ICP |
|
Total Heavy Metals |
≤10 ppm |
Conform |
ICP |
Microbiological Control: |
|||
|
E.coli |
Negative/25g |
Conform |
USP<62> |
|
Staphylococcus aureus Rosenbach |
Negative/25ç |
Conform |
USP<62> |
|
Salmonella |
Negative/25g |
Conform |
USP<62> |
|
P, aeruginosa |
Negative/25g |
Conform |
USP<62> |
|
Total Coliform |
<100 CFU/g |
Conform |
USP<62> |
|
Total Yeast and Mold Count |
≤100 CFU/s |
Conform |
|
|
Total Viable Aerobic Count |
≤1000 CFU/cm |
Conform |
|
Recommended Storage & Shelf Life
| Item | Specification |
|---|---|
| Storage Condition | Store in Cool, Dry, Light-Protected Environment |
| Packaging | Double PE Bag + Aluminum Foil Bag + Fiber Drum |
| Shelf Life | 24 Months Under Recommended Conditions |
| Recommended Temperature | Below 25°C |
| Relative Humidity | Below 60% RH |
Manufacturing Flow Description
Seed Culture → Submerged Fermentation → Centrifugal Harvesting → Membrane Filtration → Multi-stage Ion Exchange → Vacuum Concentration → Fractional Recrystallization → Vacuum Drying → Cleanroom Packaging.
Third Part Test Result
We have established partnerships with prestigious third-party laboratories, including Eurofins and SGS. Upon customer request, we are capable of arranging reinspection of L Ergothioneine Powder samples prior to shipment. Furthermore, we are fully equipped to coordinate testing with any laboratory designated by the customer to ensure their specific requirements are met.
OEM Packaging Available
Yangge Biotech Halal certificates
Over the years, we have been committed to the product manufacture optimization and quality system establishment. And we have obtained the Certificate for L- Ergothioneine Powder and all our manufactured products.
FAQ
※ Do you have factory?
Yes, we have a 1500m2 factory with modern equipment, welcome to visit our factory. When you have the details schedule, please kindly let me know in advance.
※ Do you have GMP?
All of our products are produced according to GMP standard, meanwhile, we have obtained ISO22000, Halal Certificate and so on.
※ What is your delivery time?
As usual, our delivery time is about 1~3 days after receipt of payments, however, for some special products, please kindly confirm with your sales manager in advance.
※ How can you confirm your quality?
Each batch of the goods can be shipped to you after strict inspection, if you still doubt, we can arrange the Pre-shipment Samples to your testing or to your pointed third party for retesting in advance, successfully, then we will arrange the bulk goods to you immediately.
R&D Technological Process
Exhibitions
We often attend international exhibitions, including CPhI, FIC, API, Vitafoods, SupplesideWest.
Yangge Biotech Factory
- All goods are manufactured in GMP standard facilities.
- All goods are released after inspection by our independent laboratory or third party.
- All goods are transported by professional freight companies.
Your Reliable Source for 99.99% L-Ergothioneine-YANGGE BIOTECH
At Yangge Biotech, we supply high-purity L-Ergothioneine (99.99%) with reliable quality and consistent supply. Product specifications and quality documents are available upon request.
For L- Ergothioneine Powder there are different specification for your choice, we can provide 10-30g of free samples, US warehouse in stock of 500kg of each month for the market of the global. certificate of analysis (COA), MSDS, specification sheet, pricing quotation is obtainable upon your request.
Looking for a reliable L-Ergothioneine supplier? Contact Yangge Biotech today for samples, pricing, and product information welcome to e-mail: info@yanggebiotech.com
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