Views:0 Author:Gigi Publish Time: 2021-10-12 Origin:Site
Ganoderma is a well-known Chinese medicine recorded in the "Pharmacopoeia". It is used to treat cancer, immune disorders, hepatitis and neuropathy, and has been proven to improve immunity. Ganoderma is rich in various biologically active compounds, mainly polysaccharides, triterpenes, nucleotides and steroids, which are called physiologically active substances. Most Ganoderma lucidum polysaccharides and triterpenes are extracted from its fruiting bodies and are considered to be the medicinal part of this fungus. However, many of these natural substances are indigestible, allowing them to pass through the upper gastrointestinal tract and be fermented by a series of gut microbes in the cecum and colon.
The fermentation of natural products by probiotics improves nutritional diversity and biological activity, including anti-microbial, anti-cancer and anti-diabetic properties, as well as intestinal regulation, immune system stimulation and cholesterol reduction. Ganoderma lucidum water extract fermented by bifidobacteria and lactobacillus sakei may help to enhance learning, memory and cognitive functions through cholinergic dysfunction. Few studies have investigated the effects of Ganoderma lucidum fermented by probiotics on the immune system. Therefore, Li Ming of Dalian Medical University, Wang Chaoran of Dalian Institute of Chemical Physics, Chinese Academy of Sciences, and their team published a study in Biomedicine and Pharmacotherapy, aiming to evaluate the Ganoderma lucidum fruiting body water extract fermented by Lactobacillus acidophilus and Bifidobacterium breve. Ganoderma lucidum fermentation broth (GLFB) Enhancement of immune function, mucosal barrier function and intestinal microbiota composition of immunosuppressive mice treated with dexamethasone (DEX) and its possible mechanism.
In this study, the researchers found that the probiotic mixture fermented Ganoderma lucidum water extract improved the immunity, mucosal barrier function and gut microbiota composition of DEX-treated mice. After fermentation by Lactobacillus acidophilus and Bifidobacterium breve, the dominant triterpene GA (ganoderic acid A) in Ganoderma lucidum is bioconverted into GC2 (ganoderic acid C2), which is the main reducing metabolite of GA. It is suggested that the fermentation of probiotics promotes the metabolism of gibberellin. RNA-seq results show that GA activates multiple pathways involved in the metabolism of Lactobacillus acidophilus and Bacillus brevis, which is consistent with the results of studies that Ganoderma lucidum broken spores regulate multiple signaling pathways involved in metabolism.
In summary, in view of the interaction between GA and probiotic strains, it is feasible that the biotransformation of GA and the metabolism of bacterial strains will greatly promote the immune regulation of GLFB. In addition, GLFB can significantly improve the immune activity, intestinal barrier integrity and intestinal flora imbalance of DEX-treated mice; the immunostimulatory activity of GLFB is directly related to the increase of CD4+ T cells in the intestinal Peel’s node.