Views:0 Author:Gigi Publish Time: 2021-09-23 Origin:Site
Before analyzing the question of whether NMN raw materials can be eaten, it is necessary to first understand what is the raw material drug? The so-called bulk drug refers to the bulk drug used in the production of various preparations, which are the effective ingredients in the preparation. APIs are prepared by chemical synthesis, plant extraction or biotechnology, and their existing forms mainly include powder, crystal, and extract. Only when raw materials are processed into pharmaceutical preparations can they become medicines that can be used in clinical applications.
Chemical raw materials are not directly edible, and if the raw materials themselves are not treated with special treatment, subsequent improper storage can easily cause raw material pollution. Formal enterprises all reprocess and produce after purchasing raw materials. After adding auxiliary materials, make preparations and obtain safety. Only after certification can it be officially put on the market.
1. Chemical synthesis method: This method has simple process and low cost. In China, it is generally not allowed to obtain purer food raw materials through chemical synthesis, so it is not recommended to use chemical methods to synthesize NMN.
2. Fermentation method: It is produced by microbial fermentation. This method has low efficiency and high cost, so it is not conducive to large-scale production in the market.
3. Biological enzyme catalytic method: This method requires specific engineering enzymes to synthesize. Although the key catalytic enzyme necessary for synthesis is expensive, this method is the safest and most effective method to synthesize NMN.
Some unscrupulous manufacturers, in order to make large profits, will choose the first method-chemical synthesis in the production of NMN, without subsequent processing, directly selling the raw powder to consumers, the NMN produced in this way is actually Imports that do not meet the standards of food-grade raw materials.
From the perspective of pharmacokinetics, after oral administration of the drug, it enters different parts of the digestive tract, such as the mouth, stomach, and intestines, and finally enters the blood. In order to release the drug slowly and protect the gastric mucosa, NMN is usually encapsulated. However, the raw material of NMN on the market usually exists in the form of original powder, and the oral original powder may not be accurately and quantitatively released in the corresponding position. Therefore, the NMN can be made into a finished product to optimize the effect.
On the market, the dosage forms of NMN are generally capsules or tablets, and there are also powders and sublingual tablets. For some dosage forms, such as powders, users cannot precisely control the dosage during consumption, which will inevitably lead to improper dosage. The recommended dosage of NMN is between 250-500 mg, with a maximum of 1000 mg. At present, the clinical pharmacology and toxicology of NMN are not fully studied, so the dosage of NMN should be strictly controlled.
At present, the purity of normal NMN is very high, reaching more than 99%. If the purity of NMN is not high, and other impurities are doped in it, these impurities are particularly easy to oxidize in the air, causing the entire NMN product to turn yellow, deteriorate, and lose its original effect.
When NMN raw materials are exposed, they are easily contaminated by light or air impurities, microorganisms, heavy metals, etc., which can easily cause diseases.
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