How is NMN manufactured?
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How is NMN manufactured?

Views: 0     Author: Gigi     Publish Time: 2022-03-16      Origin: Site

Is nicotinamide mononucleotide safe

In the past two years, in the health food market, NMN is the absolute "top-class ingredient", and the popularity has remained high. After it was registered in many countries such as Europe and the United States, it began to become popular around the world. The United States has approved the R&D and production of NMN on a large scale, and has the largest NMN R&D and production system in the world; Japan is the first country to conduct human clinical trials of NMN, and has approved NMN to enter the raw material catalog of health food, to the whole society promotion.

nicotinamide mononucleotide (nmn)

Why is the magic anti-aging substance so popular?

The full name of NMN is β-Nicotinamide Mononucleotide, and the Chinese name is β-Nicotinamide Mononucleotide. In 2013, Professor David Sinclair, a professor at Harvard Medical School, and his team published a paper in the world's authoritative scientific journal Cell, which confirmed for the first time that after taking NMN for a week, the biochemical indicators of aging rats decreased due to aging. (decreased ATP content, decreased COX activity, etc.) were reversed [1]. As a traffic brother in the anti-aging industry, Sinclair has undoubtedly played a huge role in the development of NMN marketization. Since 2016, NMN has been made into dietary supplements in Japan, the United States and other countries. Around 2018, it entered the domestic market through cross-border e-commerce, and it became popular on the whole network in 2020.

At present, most of the NMN brands on the market originate from the United States and Japan. Among them, NMN in Japan has become an absolute market hotspot. According to data from the Japanese research agency Fuji Keizai, the NMN market in Japan is about 2.6 billion yen in 2020 and is expected to reach 14.8 billion yuan by 2027.

The development of NMN in the Chinese market also has great potential. According to data from iiMedia Research, China's NMN ingredient health care products market will reach 5.106 billion yuan in 2020, a year-on-year increase of 34.87%. It is expected that the market size will reach 27.013 billion yuan by 2023, and the industry is developing rapidly.

In my country, NMN is neither a food raw material nor a pharmaceutical raw material. If you want to use it as a nutritional supplement, you can only enter the country through cross-border e-commerce channels. On December 30, 2021, the State Administration for Market Regulation published the "Reply to Recommendation No. 1067 of the Fourth Session of the Thirteenth National People's Congress" (Guo Shi Jian Yi [2021] No. 206), pointing out: At present, NMN (β- The positioning and safety of nicotinamide mononucleotide) as a food raw material is still unclear, and there is a lack of national food safety standards. It is recommended to carry out safety assessments or clarify national food safety standards in accordance with new food raw materials. NMN and related products have not yet been registered as health food in my country. The conditions for NMN to be used as a raw material for health food are not yet mature, and further monitoring and research are needed. At the same time, the State Administration for Market Regulation said that in the next step, it will work with the National Health Commission, the State Food and Drug Administration and other relevant departments to support the basic research on NMN and related products, and guide the standardized development of NMN and related products.

The application of any emerging active ingredient requires a large number of long-term scientific studies to prove its safety and effectiveness on the human body. In fact, NMN-related functional experiments have achieved a large number of positive results. A large body of research evidence indicates that NAD+ is involved in a broad spectrum of cellular responses, including multiple response pathways related to cell cycle and senescence regulation.

In a variety of model organisms, increasing the level of intracellular NAD+ has been shown to prolong the lifespan of model organisms. In addition, in many animal experiments, NMN has also been shown to reduce the risk of disease in animals:

Yu and colleagues from the University of Cambridge, published in the journal Cell Death & Disease, show that dietary supplementation with NAD+, the precursor NMN, inhibits neurodegeneration in a fly model of Alzheimer's disease.

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